Creatine Monohydrate, CAS# 6020-87-7, is a nitrogenous organic acid manufactured through chemical synthesis, available as White crystal or crystallline powder. Creatine Monohydrate is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported. Creatine can cause stomach pain, nausea, diarrhea, and muscle cramping in specific groups of individuals. There is some concern that creatine might make kidney disease worse.
As Creatine Monohydrate is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Creatine Monohydrate for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
Creatine Monohydrate may have some affect on individuals with kidney disease or diabetes. We recommend consumers to consult professionals before using Creatine Monohydrate in food of individuals with kidney disease or diabetes.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Creatine Monohydrate is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Creatine Monohydrate reported up to now.
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1. The effects of creatine monohydrate supplementation with and without D-pinitol on resistance training adaptations. [J Strength Cond Res. 2009 Dec]
Author: Kerksick CM, Wilborn CD, Campbell WI, Harvey TM, Marcello BM, Roberts MD, Parker AG, Byars AG, Greenwood LD, Almada AL, Kreider RB, Greenwood M.
2. Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. [Clin J Sport Med. 2009 Sep]
Author: van der Merwe J, Brooks NE, Myburgh KH.
3. Acute renal failure in a young weight lifter taking multiple food supplements, including creatine monohydrate. [J Ren Nutr. 2006 Oct]
Author: Thorsteinsdottir B, Grande JP, Garovic VD.
4. Risk assessment for creatine monohydrate. [Regul Toxicol Pharmacol. 2006 Aug]
Author: Shao A, Hathcock JN.
5. Creatine monohydrate in DM2/PROMM: a double-blind placebo-controlled clinical study. Proximal myotonic myopathy. [Neurology. 2003 Feb 11]
Author: Schneider-Gold C, Beck M, Wessig C, George A, Kele H, Reiners K, Toyka KV.