L-Proline, CAS# 147-85-3, is a amino acid manufactured through fermentation, available as White clystals or crystalline powder. L-Proline is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As L-Proline is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of L-Proline for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that L-Proline could have any negative effects on these vulnerable groups. It should be safe to use L-Proline in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of L-Proline for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Proline is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about L-Proline reported up to now.
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1. Effects of L-proline on the Growth Performance, and Blood Parameters in Weaned Lipopolysaccharide (LPS)-challenged Pigs. [Asian-Australas J Anim Sci. 2014 Aug]
Author: Kang P, Zhang L, Hou Y, Ding B, Yi D, Wang L, Zhu H, Liu Y, Yin Y, Wu G.
2. Chiral separation and determination of amino acids in real samples by LE-MEKC using Cu(II)-l-proline as chiral selector. [J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 15]
Author: Wu Y, Zhai Y, Zhang Y, Zhang H, Jing H, Chen A.
3. Synthesis of Oligomers of β-l-Arabinofuranosides of (4R)-4-Hydroxy-l-proline Relevant to the Mugwort Pollen Allergen, Art v 1. [J Org Chem. 2014 Aug 1. ]
Author: Xie N, Taylor CM.
4. Novel inhibitors of the high-affinity l-proline transporter as potential therapeutic agents for the treatment of cognitive disorders. [Bioorg Med Chem Lett. 2014 Jul 1.]
Author: Zipp GG, Barbosa J, Green MA, Terranova KM, Fink C, Yu XC, Nouraldeen A, Wilson A, Savelieva K, Lanthorn TH, David Kimball S.
5. Clinical Experience With an L-Proline-Stabilized 10 % Intravenous Immunoglobulin (Privigen®): Real-Life Effectiveness and Tolerability. [J Clin Immunol. 2014 Jul 1. ]
Author: Dorsey MJ, Ho V, Mabudian M, Soler-Palacín P, Domínguez-Pinilla N, Rishi R, Rishi R, Wong D, Rojavin M, Hubsch A, Berger M.