L-Arginine, CAS# 749-79-33, is a amino acid manufactured through fermentation, available as White crystalline powder. L-Arginine is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported. L-Arginine can cause abdominal pain, bloating, diarrhea, gout, blood abnormalities, allergies, airway inflammation, worsening of asthma, and low blood pressure in specific groups of individuals.
As L-Arginine is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of L-Arginine for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that L-Arginine could have any negative effects on these vulnerable groups. It should be safe to use L-Arginine in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of L-Arginine for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Arginine is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about L-Arginine reported up to now.
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1. The pharmacodynamics of L-arginine. [Altern Ther Health Med. 2014 May-Jun]
Author: Böger RH.
2. A randomized pilot study of L-arginine infusion in severe falciparum malaria: preliminary safety, efficacy and pharmacokinetics. [PLoS One. 2013 Jul 29]
Author: Yeo TW, Lampah DA, Rooslamiati I, Gitawati R, Tjitra E, Kenangalem E, Price RN, Duffull SB, Anstey NM.
3. A randomized controlled trial of inhaled L-arginine in patients with cystic fibrosis. [J Cyst Fibros. 2013 Sep]
Author: Grasemann H, Tullis E, Ratjen F.
4. The effect of L-arginine on arterial stiffness and oxidative stress in chronic kidney disease. [Indian J Nephrol. 2012 Sep]
Author: Annavarajula SK, Dakshinamurty KV, Naidu MU, Reddy CP.
5. Does L-arginine supplementation play a role in cerebral small vessels disease? Implication in the treatment of leukoaraiosis. [Med Hypotheses. 2011 Oct]
Author: Calabrò RS, Gervasi G, Bramanti P.