Inosine, CAS# 58-63-9, is a nucleoside manufactured through fermentation, available as White crystalline Powder. Inosine is widely used as nutritional supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As Inosine is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Inosine for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Inosine could have any negative effects on these vulnerable groups. It should be safe to use Inosine in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Inosine for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Inosine is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Inosine reported up to now.
* Want to report news about this ingredient, please send email to foodchemmis08@foodchem.cn. Your knowledge can help us to uncover more truthes about food ingredients to customers.
1. Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. [JAMA Neurol. 2014 Feb]
Author: Parkinson Study Group SURE-PD Investigators, Schwarzschild MA, Ascherio A, Beal MF, Cudkowicz ME, Curhan GC, Hare JM, Hooper DC, Kieburtz KD, Macklin EA, Oakes D, Rudolph A, Shoulson I, Tennis MK, Espay AJ, Gartner M, Hung A, Bwala G, Lenehan R, Encarnacion E, Ainslie M, Castillo R, Togasaki D, Barles G, Friedman JH, Niles L, Carter JH, Murray M, Goetz CG, Jaglin J, Ahmed A, Russell DS, Cotto C, Goudreau JL, Russell D, Parashos SA, Ede P, Saint-Hilaire MH, Thomas CA, James R, Stacy MA, Johnson J, Gauger L, Antonelle de Marcaida J, Thurlow S, Isaacson SH, Carvajal L, Rao J, Cook M, Hope-Porche C, McClurg L, Grasso DL, Logan R, Orme C, Ross T, Brocht AF, Constantinescu R, Sharma S, Venuto C, Weber J, Eaton K.
2. Inosine enhances axon sprouting and motor recovery after spinal cord injury. [PLoS One. 2013 Dec 2]
Author: Kim D, Zai L, Liang P, Schaffling C, Ahlborn D, Benowitz LI.
3. Boosting endogenous neuroprotection in multiple sclerosis: the ASsociation of Inosine and Interferon beta in relapsing- remitting Multiple Sclerosis (ASIIMS) trial. [Mult Scler. 2010 Apr]
Author: Gonsette RE, Sindic C, D'hooghe MB, De Deyn PP, Medaer R, Michotte A, Seeldrayers P, Guillaume D; ASIIMS study group.
4. Inosine improves islet xenograft survival in immunocompetent diabetic mice. [Eur J Med Res. 2005 Jul 29]
Author: Schneider S, Klein HH.