L-Citrulline, CAS# 372-75-8, is a α-amino acid manufactured through fermentation, available as White crystals or crystalline Powder. L-Citrulline is widely used as nutritional supplements. It is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries.
No significant side effects reported.
As L-Citrulline is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of L-Citrulline for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that L-Citrulline could have any negative effects on these vulnerable groups. It should be safe to use L-Citrulline in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of L-Citrulline for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Citrulline is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about L-Citrulline reported up to now.
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1. [The role of L-arginine and L-citrulline on atherosclerosis]. [Seikagaku. 2014 Jun]
Author: Hayashi T.
2. l-Citrulline, But Not l-Arginine, Prevents Diabetes Mellitus-Induced Glomerular Hyperfiltration and Proteinuria in Rat. [Hypertension. 2014 May 27.]
Author: Persson P, Fasching A, Teerlink T, Hansell P, Palm F.
3. L-citrulline provides a novel strategy for treating chronic pulmonary hypertension in newborn infants. [Acta Paediatr. 2014 May 26]
Author: Fike CD, Summar M, Aschner JL.