L-Leucine, CAS# 61-90-5, is a hydrophobic amino acid manufactured through chemical synthesis, available as white powder. L-Leucine is widely used as nutritional supplements. It is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries with E number E641.
No significant side effects reported.
As L-Leucine is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of L-Leucine for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that L-Leucine could have any negative effects on these vulnerable groups. It should be safe to use L-Leucine in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of L-Leucine for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Leucine is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about L-Leucine reported up to now.
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1. Synthesis and Toxicological Evaluation of a Chitosan-L-Leucine Conjugate for Pulmonary Drug Delivery Applications. [Biomacromolecules. 2014 Sep 5]
Author: Muhsin MD, George GA, Beagley K, Ferro V, Armitage C, Islam N.
2. L-leucine, beta-hydroxy-beta-methylbutyric acid (HMB) and creatine monohydrate prevent myostatin-induced Akirin-1/Mighty mRNA down-regulation and myotube atrophy. [J Int Soc Sports Nutr. 2014 Aug 13]
Author: Mobley CB, Fox CD, Ferguson BS, Amin RH, Dalbo VJ, Baier S, Rathmacher JA, Wilson JM, Roberts MD.
3. L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way. [Br J Haematol. 2014 Aug 7]
Author: Narla A, Payne EM, Abayasekara N, Hurst SN, Raiser DM, Look AT, Berliner N, Ebert BL, Khanna-Gupta A.
4. L-Leucine for gold nanoparticles synthesis and their cytotoxic effects evaluation. [Amino Acids. 2014 Aug 5]
Author: Berghian-Grosan C, Olenic L, Katona G, Perde-Schrepler M, Vulcu A.