Formononetin, CAS# 485-72-3, is a O-methylated isoflavone manufactured through plant extraction, available as White fine powder. Formononetin is widely used as nutritional supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As Formononetin is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Formononetin for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Formononetin could have any negative effects on these vulnerable groups. It should be safe to use Formononetin in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Formononetin for long period in food for newborns or pregnant.
Though Formononetin is not on FDA's GRAS exemption list, it's still widely accepted as safe food additive in many countries including USA with specific limit on dosage.
No breaking news or public health crises reported about Formononetin reported up to now.
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1. The Proapoptotic Effect of Formononetin in Human Osteosarcoma Cells: Involvement of Inactivation of ERK and Akt Pathways. [Cell Physiol Biochem. 2014 Aug 12]
Author: Liu Y, He J, Chen X, Li J, Shen M, Yu W, Yang Y, Xiao Z.
2. Formononetin attenuates hydrogen peroxide (H2O2)-induced apoptosis and NF-κB activation in RGC-5 cells. [Eur Rev Med Pharmacol Sci. 2014]
Author: Jia WC, Liu G, Zhang CD, Zhang SP.
3. Insect-induced daidzein, formononetin and their conjugates in soybean leaves. [Metabolites. 2014 Jul 4]
Author: Murakami S, Nakata R, Aboshi T, Yoshinaga N, Teraishi M, Okumoto Y, Ishihara A, Morisaka H, Huffaker A, Schmelz EA, Mori N.
4. Formononetin mediates neuroprotection against cerebral ischemia/reperfusion in rats via downregulation of the Bax/Bcl-2 ratio and upregulation PI3K/Akt signaling pathway. [J Neurol Sci. 2014 Sep 15]
Author: Liang K, Ye Y, Wang Y, Zhang J, Li C.