Genistein, CAS# 446-72-0, is a phytoestrogen manufactured through plant extraction, available as White powder. Genistein is widely used as nutritional supplements. It is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries.
No significant side effects reported.
As Genistein is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Genistein for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Genistein could have any negative effects on these vulnerable groups. It should be safe to use Genistein in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Genistein for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Genistein is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Genistein reported up to now.
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1. Genistein suppresses the isoproterenol-treated H9c2 cardiomyoblast cell apoptosis associated with P-38, Erk1/2, JNK, and NFκB signaling protein activation. [Am J Chin Med. 2013]
Author: Hu WS, Lin YM, Ho TJ, Chen RJ, Li YH, Tsai FJ, Tsai CH, Day CH, Chen TS, Huang CY.
2. Retinal toxicity of intravitreal genistein in a rabbit model. [Retina. 2010 Oct]
Author: Fiore T, Iaccheri B, Pietrolucci F, Giansanti F, Cavaliere A, Coltella R, Mameli MG, Androudi S, Brazitikos P, Cagini C.
3. Study on the pharmacokinetics of synthetic genistein after multiple oral intake in post-menopausal women. [Arzneimittelforschung. 2009]
Author: Metzner JE, Frank T, Kunz I, Burger D, Riegger C.
4. Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer. [J Nutr. 2007 Jan]
Author: Swami S, Krishnan AV, Moreno J, Bhattacharyya RB, Peehl DM, Feldman D.