Synephrine HCl, CAS# 5985-28-4, is a hydrochloride salt of synephrine manufactured through chemical synthesis, available as white powder. Synephrine Hcl is widely used as nutritional supplements. It is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries.
No significant side effects reported.
As Synephrine HCl is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Synephrine HCl for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Synephrine HCl could have any negative effects on these vulnerable groups. It should be safe to use Synephrine HCl in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Synephrine HCl for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Synephrine HCl is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Synephrine HCl reported up to now.
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1. The treatment of prolonged arterial hypotension with continuous intravenous infusions of neo-synephrine hydrochloride. [Bull New Engl Med Cent. 1954 Mar]
Author: RHEINLANDER HF, KAPLAN RM, ETSTEN B.
2. Use of phenylephrine hydrochloride, neo-synephrine hydrochloride, in ophthalmology. [Arch Ophthal. 1949 Feb]
Author: HEATH P, GEITER CW.