Luteolin, CAS# 491-70-3, is a flavone manufactured through plant extraction or chemical synthesis, available as Yellow Powder. Luteolin is widely used as nutritional supplements. It is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries.
No significant side effects reported.
As Luteolin is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Luteolin for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Luteolin could have any negative effects on these vulnerable groups. It should be safe to use Luteolin in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Luteolin for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Luteolin is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Luteolin reported up to now.
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1. Luteolin reduces Alzheimer's disease pathologies induced by traumatic brain injury. [Int J Mol Sci. 2014 Jan 9]
Author: Sawmiller D, Li S, Shahaduzzaman M, Smith AJ, Obregon D, Giunta B, Borlongan CV, Sanberg PR, Tan J.
2. Mode of peroxisome proliferator-activated receptor γ activation by luteolin. [Mol Pharmacol. 2012 Jun]
Author: Puhl AC, Bernardes A, Silveira RL, Yuan J, Campos JL, Saidemberg DM, Palma MS, Cvoro A, Ayers SD, Webb P, Reinach PS, Skaf MS, Polikarpov I.