Rutaecarpine, CAS# 84-26-4, is a COX-2 inhibitor manufactured through extraction from evodia rutaecarpa, available as white powder. Rutaecarpine is widely used as nutritional supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As Rutaecarpine is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Rutaecarpine for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Rutaecarpine could have any negative effects on these vulnerable groups. It should be safe to use Rutaecarpine in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Rutaecarpine for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Rutaecarpine is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Rutaecarpine reported up to now.
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1. Neuroprotective effects of rutaecarpine on cerebral ischemia reperfusion injury. [Neural Regen Res. 2013 Aug 5]
Author: Yan C, Zhang J, Wang S, Xue G, Hou Y.
2. Optimization of Rutaecarpine as ABCA1 Up-Regulator for Treating Atherosclerosis. [ACS Med Chem Lett. 2014 Jun 24]
Author: Li Y, Feng T, Liu P, Liu C, Wang X, Li D, Li N, Chen M, Xu Y, Si S.
3. Rutaecarpine suppresses atherosclerosis in ApoE-/- mice through upregulating ABCA1 and SR-BI within RCT. [J Lipid Res. 2014 Jun 7]
Author: Xu Y, Liu Q, Xu Y, Liu C, Wang X, He X, Zhu N, Liu J, Wu Y, Li Y, Li N, Feng T, Lai F, Zhang M, Hong B, Jiang JD, Si S.
4. Evodiamine and rutaecarpine alkaloids as highly selective transient receptor potential vanilloid 1 agonists. [Int J Biol Macromol. 2014 Apr]
Author: Ivanova B, Spiteller M.