Mannitol, CAS# 87-78-5, is a sugar alcohol manufactured through chemical synthesis, available as WHITE CRYSTALLINE POWDER. Mannitol is widely used as sweetener. It is widely accepted as safe food additive in many countries with E number E421.
Mannitol is generally safe when used in food dosage level. Mannitol can cause various allergic reaction including dry mouth, increased thirst, blurred vision, convulsions swelling, pain, or skin changes where the medicine was injected when used in higher medical dosage level.
As Mannitol is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Mannitol for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Mannitol could have any negative effects on these vulnerable groups. It should be safe to use Mannitol in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Mannitol for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Mannitol is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Mannitol reported up to now.
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1. Food consumption and body weight changes with neotame, a new sweetener with intense taste: differentiating effects of palatability from toxicity in dietary safety studies. [Regul Toxicol Pharmacol. 2003 Oct]
Author: Mayhew DA, Comer CP, Stargel WW.