D-Glucuronolactone, CAS# 32449-92-6, is a natural organic compound manufactured through chemical synthesis, available as White crystalline powder. D-Glucuronolactone is widely used as nutritional supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As D-Glucuronolactone is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of D-Glucuronolactone for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that D-Glucuronolactone could have any negative effects on these vulnerable groups. It should be safe to use D-Glucuronolactone in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of D-Glucuronolactone for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. D-Glucuronolactone is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about D-Glucuronolactone reported up to now.
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1. Formation of alpha-amino-gamma, delta-dihydroxyadipic acid by boiling D-glucuronolactone and urea in 6 mol/1 hydrochloric acid. [Clin Chim Acta. 1986 Nov 15]
Author: Yuasa S.
2. Comparison of D-glucuronolactone and aldehyde dehydrogenase activities in the rat liver. [Med Biol. 1977 Apr]
Author: Törrönen R, Marselos M.
3. Effects of D-glucuronolactone, L-gulonolactone and penitols on insulin secretion in dogs. [Endocrinol Jpn. 1973 Aug]
Author: Kuzuya T, Kanazawa Y, Kikuchi M, Ide T.
4. Common properties of D-glucuronolactone and aldehyde dehydrogenase from the soluble fraction of rat liver. [Biochim Biophys Acta. 1972 Apr 7]
Author: Aarts EM, Hinnen-Bouwmans C.