MethylSulfonylMethane, CAS# 67-71-0, is a organosulfur compound manufactured through chemical synthesis, available as White Crystals or crystalline powder. Methylsulfonylmethane is widely used as nutritional supplements. It is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries.
No significant side effects reported.
As MethylSulfonylMethane is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of MethylSulfonylMethane for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that MethylSulfonylMethane could have any negative effects on these vulnerable groups. It should be safe to use MethylSulfonylMethane in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of MethylSulfonylMethane for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. MethylSulfonylMethane is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about MethylSulfonylMethane reported up to now.
* Want to report news about this ingredient, please send email to foodchemmis08@foodchem.cn. Your knowledge can help us to uncover more truthes about food ingredients to customers.
1. Methylsulfonylmethane modulates apoptosis of LPS/IFN-γ-activated RAW 264.7 macrophage-like cells by targeting p53, Bax, Bcl-2, cytochrome c and PARP proteins. [Immunopharmacol Immunotoxicol. 2014 Sep 11]
Author: Karabay AZ, Aktan F, Sunguroğlu A, Buyukbingol Z.
2. Effect of single dose administration of methylsulfonylmethane on oxidative stress following acute exhaustive exercise. [Iran J Pharm Res. 2013 Fall]
Author: Nakhostin-Roohi B, Niknam Z, Vaezi N, Mohammadi S, Bohlooli S.
3. Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in mice. [Inflammation. 2013 Oct]
Author: Amirshahrokhi K, Bohlooli S.
4. Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in mice. [Inflammation. 2013 Oct]
Author: Amirshahrokhi K, Bohlooli S.