Natamycin, CAS# 7681-93-8, is a naturally occurring antifungal agent manufactured through fermentation using bacterium Streptomyces natalensis, available as Off-white crystalline powder. Natamycin is widely used as preservative as it can inhibit fungal outgrowth in food. It is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries with E number E235.
No significant side effects reported.
Ingestion of Natamycin in large quantity may hurt our health, please follow the guideline of using Natamycin: ADI 0-0.3 mg/kg bw
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Natamycin could have any negative effects on these vulnerable groups. It should be safe to use Natamycin in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Natamycin for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Natamycin is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Natamycin reported up to now.
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1. Voriconazole versus natamycin as primary treatment in fungal corneal ulcers. [Clin Experiment Ophthalmol. 2011 Jul]
Author: Arora R, Gupta D, Goyal J, Kaur R.
2. Successful salvage treatment of Scedosporium apiospermum keratitis with topical voriconazole after failure of natamycin. [Ann Pharmacother. 2009 Jun]
Author: Al-Badriyeh D, Leung L, Davies GE, Stewart K, Kong D.