Nisin, CAS# 1414-45-5, is a polycyclic antibacterial peptide manufactured through fermentation using the bacterium Lactococcus lactis, available as Light brown to cream white powder. Nisin is widely used as preservative as it can inhibit a wide range of bacteria in food. It is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries with E number E234.
No significant side effects reported.
Ingestion of Nisin in large quantity may hurt our health, please follow the guideline of using Nisin: ADI 0–2 mg/kg bw
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Nisin could have any negative effects on these vulnerable groups. It should be safe to use Nisin in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Nisin for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Nisin is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Nisin reported up to now.
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1. Genome shuffling of Lactococcus lactis subspecies lactis YF11 for improving nisin Z production and comparative analysis. [J Dairy Sci. 2014 May]
Author: Zhang YF, Liu SY, Du YH, Feng WJ, Liu JH, Qiao JJ.
2. Activate to eradicate: inhibition of Clostridium difficile spore outgrowth by the synergistic effects of osmotic activation and nisin. [PLoS One. 2013]
Author: Nerandzic MM, Donskey CJ.
3. Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1. [Cancer Med. 2012 Dec]
Author: Joo NE, Ritchie K, Kamarajan P, Miao D, Kapila YL.
4. Evaluation of antimicrobial peptide nisin as a safe vaginal contraceptive agent in rabbits: in vitro and in vivo studies. [Reproduction. 2004 Jul]
Author: Reddy KV, Aranha C, Gupta SM, Yedery RD.