No significant side effects reported.
As L-Citrulline Malate is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of L-Citrulline Malate for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that L-Citrulline Malate could have any negative effects on these vulnerable groups. It should be safe to use L-Citrulline Malate in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of L-Citrulline Malate for long period in food for newborns or pregnant.
Though L-Citrulline Malate is not on FDA's GRAS exemption list, it's still widely accepted as safe food additive in many countries including USA with specific limit on dosage.
No breaking news or public health crises reported about L-Citrulline Malate reported up to now.
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1. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: A clinical trial. [J Cardiol. 2014 Feb 10]
Author: Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, Behzadnia N, Sheybani-Afshar F, Fakhri M, Chaibakhsh S, Naghashzadeh F, Aidenlou S.
2. L-citrulline-malate influence over branched chain amino acid utilization during exercise. [Eur J Appl Physiol. 2010 Sep]
Author: Sureda A, Córdova A, Ferrer MD, Pérez G, Tur JA, Pons A.