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 L-Citrulline Malate Side Effects

    L-Citrulline Malate Side Effects

    by Daniel Peng 2014-08-24

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    General Side Effects

    No significant side effects reported.


    * Report new side effects to us by sending email to foodchemmis08@foodchem.cn. Our expert will review it and respond soon.

    Suggested Dosage

    As L-Citrulline Malate is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of L-Citrulline Malate for long period.


    * ADI: Acceptable Daily Intake
    * MTDI: maximum tolerable daily intake
    * Data source: JECFA Database of WHO

    Special Groups Precaution

    Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
    There is no evidence that L-Citrulline Malate could have any negative effects on these vulnerable groups. It should be safe to use L-Citrulline Malate in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of L-Citrulline Malate for long period in food for newborns or pregnant.

    GRAS Affirmation: No

    Though L-Citrulline Malate is not on FDA's GRAS exemption list, it's still widely accepted as safe food additive in many countries including USA with specific limit on dosage.

    in News

    No breaking news or public health crises reported about L-Citrulline Malate reported up to now.
    * Want to report news about this ingredient, please send email to foodchemmis08@foodchem.cn. Your knowledge can help us to uncover more truthes about food ingredients to customers.

    Related Research

    1. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: A clinical trial. [J Cardiol. 2014 Feb 10]
    Author: Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, Behzadnia N, Sheybani-Afshar F, Fakhri M, Chaibakhsh S, Naghashzadeh F, Aidenlou S.

    2. L-citrulline-malate influence over branched chain amino acid utilization during exercise. [Eur J Appl Physiol. 2010 Sep]
    Author: Sureda A, Córdova A, Ferrer MD, Pérez G, Tur JA, Pons A.



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