Betulinic Acid, CAS# 472-15-1, is a Plant extracts manufactured through plant extraction, available as White Powder . Betulinic Acid is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As Betulinic Acid Side Effects is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Betulinic Acid Side Effects for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Betulinic Acid Side Effects could have any negative effects on these vulnerable groups. It should be safe to use Betulinic Acid Side Effects in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Betulinic Acid Side Effects for long period in food for newborns or pregnant.
Though Betulinic Acid Side Effects is not on FDA's GRAS exemption list, it's still widely accepted as safe food additive in many countries including USA with specific limit on dosage.
No health issues about Betulinic Acid Side Effects reported up to now.
1. Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acidinduces cell cycle arrest and apoptosis in cancer cells of different origin. [Cell Death Dis. 2014 Oct 9]
Author: Majeed R, Hamid A, Sangwan PL, Chinthakindi PK, Koul S, Rayees S, Singh G, Mondhe DM, Mintoo MJ, Singh SK, Rath SK, Saxena AK.
2. Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer. [Mol Cancer Ther. 2012 Jul]
Author: Liu X, Jutooru I, Lei P, Kim K, Lee SO, Brents LK, Prather PL, Safe S.
3. Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10. [Mol Carcinog. 2013 Aug]
Author: Mertens-Talcott SU, Noratto GD, Li X, Angel-Morales G, Bertoldi MC, Safe S.
4. Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors. [BMC Cancer. 2011 Aug 24]
Author: Chintharlapalli S, Papineni S, Lei P, Pathi S, Safe S.