D-Biotin, CAS# 58-85-5, is a organic compound manufactured through chemical synthesis, available as White crystal powder. D-Biotin is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As D-Biotin is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of D-Biotin for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that D-Biotin could have any negative effects on these vulnerable groups. It should be safe to use D-Biotin in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of D-Biotin for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. D-Biotin is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about D-Biotin reported up to now.
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1. Why 1-NH and 3-NH protons of D-biotin exhibit different activities in aqueous solution. [J Phys Chem B. 2008 Jul 24]
Author: Zhang L, Hu X, Li H.
2. Detection of carbonyl-modified proteins in interfibrillar rat mitochondria using N'-aminooxymethylcarbonylhydrazino-D-biotin as an aldehyde/keto-reactive probe in combination with Western blot analysis and tandem mass spectrometry. [Electrophoresis. 2008 Mar]
Author: Chung WG, Miranda CL, Maier CS.
3. New role for an old probe: affinity labeling of oxylipid protein conjugates by N'-aminooxymethylcarbonylhydrazino d-biotin. [Anal Chem. 2006 Oct 1]
Author: Chavez J, Wu J, Han B, Chung WG, Maier CS.
4. Synthetic studies on d-biotin, part 9. An improved asymmetric synthetic route to d-biotin via Hoffmann-Roche lactone-thiolactone approach. [Chem Pharm Bull (Tokyo). 2005 Jul]
Author: Chen FE, Jia HQ, Chen XX, Dai HF, Xie B, Kuang YY, Zhao JF.
5. A switch of reactivity profile in ionic intramolecular annulation reactions: a short and efficient synthesis of D-+-biotin. [J Org Chem. 2001 Sep 7]
Author: Chavan SP, Tejwani RB, Ravindranathan T.