Nicotinic Acid, CAS# 59-67-6, is a vitamin manufactured through chemical synthesis, available as White Crystalline powder. Nicotinic Acid is widely used as nutritional supplements as it's one of the 20 to 80 essential human nutrients.. It is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries with E number E375.
No significant side effects reported.
As Nicotinic Acid is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Nicotinic Acid for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Nicotinic Acid could have any negative effects on these vulnerable groups. It should be safe to use Nicotinic Acid in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Nicotinic Acid for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Nicotinic Acid is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Nicotinic Acid reported up to now.
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1. Nicotinic acid activates the capsaicin receptor TRPV1: Potential mechanism for cutaneous flushing. [Arterioscler Thromb Vasc Biol. 2014 Jun]
Author: Ma L, Lee BH, Mao R, Cai A, Jia Y, Clifton H, Schaefer S, Xu L, Zheng J.
2. Effectiveness and safety of extended-release nicotinic acid for reducing serum phosphorus in hemodialysis patients. [J Nephrol. 2012 May-Jun]
Author: Aramwit P, Srisawadwong R, Supasyndh O.
3. Pleiotropic effects of nicotinic acid: beyond high density lipoprotein cholesterol elevation. [Curr Vasc Pharmacol. 2011 Jul 1]
Author: Florentin M, Liberopoulos EN, Kei A, Mikhailidis DP, Elisaf MS.
4. Comparison of simvastatin and nicotinic acid administration in alcohol-treated Wistar rats. [Hellenic J Cardiol. 2008 Mar-Apr]
Author: Kolovou GD, Salpea KD, Mihas C, Malakos I, Kafaltis N, Bilianou HG, Adamopoulou EN, Mykoniatis M, Cokkinos DV.