Propylene Glycol, CAS# 57-55-6, is a organic compound manufactured through chemical synthesis, available as Colorless transparent viscous liquid. Propylene Glycol is widely used as emulsifiers. It is widely accepted as safe food additive in many countries.
No significant side effects reported. Propylene Glycol can cause moderate to severe allergic reaction in infants, baby under 4, pregnant women and individuals with kidney dysfunction.
Ingestion of Propylene Glycol in large quantity may hurt our health, please follow the guideline of using Propylene Glycol: ADI 0-25 mg/kg bw
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
Propylene Glycol may have some affect on infant, children under 4 and pregnant. We recommend consumers to consult professionals before using Propylene Glycol in food of infant, children under 4 and pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Propylene Glycol is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Propylene Glycol reported up to now.
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1. Propylene-Glycol Aggravates LPS-Induced Sepsis through Production of TNF-α and IL-6. [Iran J Immunol. 2014 Jun]
Author: Marton A, Kolozsi C, Kusz E, Olah Z, Letoha T, Vizler C, Pecze L.
2. Safety assessment of propylene glycol, tripropylene glycol, and PPGs as used in cosmetics. [Int J Toxicol. 2012 Sep-Oct]
Author: Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.
3. Evaluation of the effect of green tea extract on mouth bacterial activity in the presence of propylene glycol. [Jundishapur J Nat Pharm Prod. 2012 Spring]
Author: Moghbel A, Farjzadeh A, Aghel N, Agheli H, Raisi N.
4. Propylene glycol produces excessive apoptosis in the developing mouse brain, alone and in combination with phenobarbital. [Pediatr Res. 2012 Jan]
Author: Lau K, Swiney BS, Reeves N, Noguchi KK, Farber NB.
5. Prospective assessment of short-term propylene glycol tolerance in neonates. [Arch Dis Child. 2010 Dec]
Author: Allegaert K, Vanhaesebrouck S, Kulo A, Cosaert K, Verbesselt R, Debeer A, de Hoon J.