Polysorbate 80, CAS# 9005-65-6, is a polysorbate surfactant manufactured through chemical synthesis, available as Lemon colored oily liqiud. Polysorbate 80 is widely used as emulsifier. It is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries with E number E433.
No significant side effects reported.
Ingestion of Polysorbate 80 in large quantity may hurt our health, please follow the guideline of using Polysorbate 80: ADI 0-25 mg/kg bw
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Polysorbate 80 could have any negative effects on these vulnerable groups. It should be safe to use Polysorbate 80 in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Polysorbate 80 for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Polysorbate 80 is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Polysorbate 80 reported up to now.
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1. [Advance of polysorbate 80 for injection accessories]. [Zhongguo Zhong Yao Za Zhi. 2011 Jul]
Author: Zhang M.
2. Development of Polysorbate 80/Phospholipid mixed micellar formation for docetaxel and assessment of its in vivo distribution in animal models. [Nanoscale Res Lett. 2011 Apr 20]
Author: Song H, Geng H, Ruan J, Wang K, Bao C, Wang J, Peng X, Zhang X, Cui D.
3. Polysorbate 80 inhibition of Pseudomonas aeruginosa biofilm formation and its cleavage by the secreted lipase LipA. [Antimicrob Agents Chemother. 2009 Jan]
Author: Toutain-Kidd CM, Kadivar SC, Bramante CT, Bobin SA, Zegans ME.
4. Permeabilisation and solubilisation of soybean phosphatidylcholine bilayer vesicles, as membrane models, by polysorbate, Tween 80. [Eur J Pharm Sci. 2005 Nov]
Author: Simões SI, Tapadas JM, Marques CM, Cruz ME, Martins MB, Cevc G.