L-Serine, CAS# 56-45-1, is a amino acid manufactured through fermentation, available as white powder. L-Serine is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
L-Serine cause no side effects based on normal usage.
As L-Serine is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of L-Serine for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that L-Serine could have any negative effects on these vulnerable groups. It should be safe to use L-Serine in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of L-Serine for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Serine is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about L-Serine reported up to now.
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1. Essentiality of de novo L-serine synthesis for embryonic development and higher functions. [Seikagaku. 2014 Jun]
Author: Furuya S, Sayano T, Esaki K.
2. Construction of an L-serine producing Escherichia coli via metabolic engineering. [J Ind Microbiol Biotechnol. 2014 Jul 6.]
Author: Gu P, Yang F, Su T, Li F, Li Y, Qi Q.
3. Effect of Cofactor Folate on the Growth of Corynebacterium glutamicum SYPS-062 and L-Serine Accumulation. [Appl Biochem Biotechnol. 2014 May 25]
Author: Zhang X, Xu G, Li H, Dou W, Xu Z.
4. L-serine treatment may improve neurorestoration of rats after permanent focal cerebral ischemia potentially through improvement of neurorepair. [PLoS One. 2014 Mar 26]
Author: Sun L, Qiang R, Yang Y, Jiang ZL, Wang GH, Zhao GW, Ren TJ, Jiang R, Xu LH.
5. Ruthenium-nitrosyl complexes with glycine, L-alanine, L-valine, L-proline, D-proline, L-serine, L-threonine, and L-tyrosine: synthesis, X-ray diffraction structures, spectroscopic and electrochemical properties, and antiproliferative activity. [Inorg Chem. 2014 Mar 3]
Author: Rathgeb A, Böhm A, Novak MS, Gavriluta A, Dömötör O, Tommasino JB, Enyedy EA, Shova S, Meier S, Jakupec MA, Luneau D, Arion VB.