Saccharin Sodium, CAS# 128-44-9, is a organic chemicals manufactured through chemical synthesis, available as white crystal or powder. Saccharin Sodium is widely used as sweeteners. It is widely accepted as safe food additive in many countries with E number E954.
Saccharin sodium was suspected as a potential factor causing bladder tumor. However, recent research proved that saccharin sodium will not cause bladder tumor in human. Saccharin sodium can cause allergic reactions in some individuals.
Ingestion of Saccharin Sodium in large quantity may hurt our health, please follow the guideline of using Saccharin Sodium: ADI 5 mg/kg body weight for saccharin
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
Saccharin Sodium may have some affect on infant, children under 4 and pregnent. We recommend consumers to consult professionals before using Saccharin Sodium in food of infant, children under 4 and pregnent.
Though Saccharin Sodium is not on FDA's GRAS exemption list, it's still widely accepted as safe food additive in many countries including USA with specific limit on dosage.
No breaking news or public health crises reported about Saccharin Sodium reported up to now.
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1. Synthesis of some new benzisothiazolone and benzenesulfonamide derivatives of biological interest starting from saccharin sodium. [Arch Pharm (Weinheim). 2013 Oct]
Author: El-Sabbagh OI.
2. [Simultaneous determination of saccharin sodium and synthetic colours in flavourings by solid phase extraction and high performance liquid chromatography]. [Se Pu. 2013 May]
Author: Zhao F, Gao G, Na H, Ma D, Wang X.
3. [Rapid determination of saccharin sodium in ice cream by high performance liquid chromatography (HPLC)]. [Se Pu. 1999 Jul]
Author: Zhang X, Zhang W, Dai J.
4. H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts. [Cancer Res. 1991 Jul 1]
Author: Masui T, Mann AM, Macatee TL, Okamura T, Garland EM, Fujii H, Pelling JC, Cohen SM
5. Comparative bladder tumor promoting activity of sodium saccharin, sodium ascorbate, related acids, and calcium salts in rats. [Cancer Res. 1991 Apr 1]
Author: Cohen SM, Ellwein LB, Okamura T, Masui T, Johansson SL, Smith RA, Wehner JM, Khachab M, Chappel CI, Schoenig GP, et al.