Sodium Citrate, CAS# 68-04-2, is a organic chemicals manufactured through fermentation, available as Colorless or white crystalline granule or crystalline powder odorless. Sodium Citrate is widely used as acidulants. It is widely accepted as safe food additive in many countries with E number E331.
As Sodium Citrate is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Sodium Citrate for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Sodium Citrate could have any negative effects on these vulnerable groups. It should be safe to use Sodium Citrate in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Sodium Citrate for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Sodium Citrate is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Sodium Citrate reported up to now.
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1. Loss of antimicrobial effect of trisodium citrate due to 'lock' spillage from haemodialysis catheters. [Nephrol Dial Transplant. 2014 Apr]
Author: Schilcher G, Schneditz D, Ribitsch W, Horina JH, Hoenigl M, Valentin T, Rosenkranz AR, Krause R.
2. Facile synthesis of alumina hollow microspheres via trisodium citrate-mediated hydrothermal process and their adsorption performances for p-nitrophenol from aqueous solutions. [J Colloid Interface Sci. 2013 Mar 15]
Author: Zhou J, Wang L, Zhang Z, Yu J.
3. Incompatibility of contrast medium and trisodium citrate. [Cardiovasc Intervent Radiol. 2013 Feb]
Author: Delcour C, Bruninx G.
4. Evaluation of interparticle interaction between colloidal Ag nanoparticles coated with trisodium citrate and safranine by using FRET: spectroscopic and mechanistic approach. [J Photochem Photobiol B. 2012 Aug 1]
Author: Mokashi VV, Gore AH, Sudarsan V, Rath MC, Han SH, Patil SR, Kolekar GB.
5. Trisodium citrate induced protein precipitation in haemodialysis catheters might cause pulmonary embolism. [Nephrol Dial Transplant. 2012 Jul]
Author: Schilcher G, Scharnagl H, Horina JH, Ribitsch W, Rosenkranz AR, Stojakovic T, Polaschegg HD.