Punicalagin, CAS# 65995-63-3, is a Plant extracts manufactured through plant extraction, available as Brown powder. Punicalagin is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As Punicalagin Side Effects is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Punicalagin Side Effects for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Punicalagin Side Effects could have any negative effects on these vulnerable groups. It should be safe to use Punicalagin Side Effects in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Punicalagin Side Effects for long period in food for newborns or pregnant.
Though Punicalagin Side Effects is not on FDA's GRAS exemption list, it's still widely accepted as safe food additive in many countries including USA with specific limit on dosage.
No health issues about Punicalagin Side Effects reported up to now.
1. The anti-infective activity of punicalagin against Salmonella enterica subsp. enterica serovar typhimurium in mice. [Food Funct. 2015 Jul 8]
Author: Li G, Feng Y, Xu Y, Wu Q, Han Q, Liang X, Yang B, Wang X, Xia X.
2. Punicalagin attenuates osteoclast differentiation by impairing NFATc1 expression and blocking Akt- and JNK-dependent pathways. [Mol Cell Biochem. 2015 Jun 6]
Author: Iwatake M, Okamoto K, Tanaka T, Tsukuba T.
3. Punicalagin Induces Nrf2/HO-1 Expression via Upregulation of PI3K/AKT Pathway and Inhibits LPS-Induced Oxidative Stress in RAW264.7 Macrophages. [Mediators Inflamm. 2015]
Author: Xu X, Li H, Hou X, Li D, He S, Wan C, Yin P, Liu M, Liu F, Xu J.
4. Punicalagin attenuated cerebral ischemia-reperfusion insult via inhibition of proinflammatory cytokines, up-regulation of Bcl-2, down-regulation of Bax, and caspase-3. [Mol Cell Biochem. 2015 Apr]
Author: Yaidikar L, Thakur S.