White Willow Bark Extract, CAS# 138-52-3, is a Plant extracts manufactured through plant extraction, available as Brown Powder. White Willow Bark Extract is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As White Willow Bark Extract is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of White Willow Bark Extract for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that White Willow Bark Extract could have any negative effects on these vulnerable groups. It should be safe to use White Willow Bark Extract in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of White Willow Bark Extract for long period in food for newborns or pregnant.
Though White Willow Bark Extract is not on FDA's GRAS exemption list, it's still widely accepted as safe food additive in many countries including USA with specific limit on dosage.
No health issues about White Willow Bark Extract reported up to now.
1. Salicin, an extract from white willow bark, inhibits angiogenesis by blocking the ROS-ERK pathways. [Phytother Res. 2014 Aug]
Author: Kong CS, Kim KH, Choi JS, Kim JE, Park C, Jeong JW.
2. White willow bark induced acute respiratory distress syndrome. [N Am J Med Sci. 2013 May]
Author: Srivali N, Cheungpasitporn W, Chongnarungsin D, Edmonds LC.
3. Fortified extract of red berry, Ginkgo biloba, and white willow bark in experimental early diabetic retinopathy. [J Diabetes Res. 2013]
Author: Bucolo C, Marrazzo G, Platania CB, Drago F, Leggio GM, Salomone S.
4. Dimeric procyanidins: screening for B1 to B8 and semisynthetic preparation of B3, B4, B6, And B8 from a polymeric procyanidin fraction of white willow bark (Salix alba). [J Agric Food Chem. 2010 Jul 14]
Author: Esatbeyoglu T, Wray V, Winterhalter P.