Betaine Monohydrate, CAS# 590-47-6, is a Betaine derivative manufactured through chemical synthesis, available as White Crystals or crystalline powder. Betaine Monohydrate is widely used as nutritional supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As Betaine Monohydrate is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Betaine Monohydrate for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Betaine Monohydrate could have any negative effects on these vulnerable groups. It should be safe to use Betaine Monohydrate in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Betaine Monohydrate for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Betaine Monohydrate is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Betaine Monohydrate reported up to now.
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1. Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets. [PLoS One. 2014 Aug 25]
Author: Cai D, Jia Y, Song H, Sui S, Lu J, Jiang Z, Zhao R.
2. Higher serum concentrations of betaine rather than choline is associated with better profiles of DXA-derived body fat and fat distribution in Chinese adults. [Int J Obes (Lond). 2014 Aug 25]
Author: Chen YM, Liu Y, Liu YH, Wang X, Guan K, Zhu HL.
3. RNAi-directed downregulation of betaine aldehyde dehydrogenase 1 (OsBADH1) results in decreased stress tolerance and increased oxidative markers without affecting glycine betaine biosynthesis in rice (Oryza sativa). [Plant Mol Biol. 2014 Aug 24]
Author: Tang W, Sun J, Liu J, Liu F, Yan J, Gou X, Lu BR, Liu Y.
4. Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury. [Biomarkers. 2014 Aug 21]
Author: Ma H, Ning J, Jin X, Mao C, Bu X, Wang M, Liu H, Wang K, Lausted C, Hood L, Chen J, Hu Z.