γ-Aminobutyric acid (GABA), CAS# 56-12-2, is a organic chemicals manufactured through chemical synthesis, available as white crystal, pale yellow Powder. Gamma-Aminobutyric Acid is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As gamma-Aminobutyric acid is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of gamma-Aminobutyric acid for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that gamma-Aminobutyric acid could have any negative effects on these vulnerable groups. It should be safe to use gamma-Aminobutyric acid in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of gamma-Aminobutyric acid for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. gamma-Aminobutyric acid is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about gamma-Aminobutyric acid reported up to now.
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1. Production of gaba (γ - Aminobutyric acid) by microorganisms: a review. [Braz J Microbiol. 2012 Oct]
Author: Dhakal R, Bajpai VK, Baek KH.
2. Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice. [PLoS One. 2011]
Author: Tian J, Dang HN, Yong J, Chui WS, Dizon MP, Yaw CK, Kaufman DL.
3. Production of gamma-aminobutyric acid by Lactobacillus brevis NCL912 using fed-batch fermentation. [Microb Cell Fact. 2010 Nov 12]
Author: Li H, Qiu T, Huang G, Cao Y.
4. Lactic acid bacterial cell factories for gamma-aminobutyric acid. [Amino Acids. 2010 Nov]
Author: Li H, Cao Y.