Coumarin, CAS# 91-64-5, is a fragrant organic compound manufactured through chemical synthesis, available as colorless crystal. Coumarin is widely used as flavour enhancer. It is widely accepted as food additive in many countries.
No significant side effects reported.
As Coumarin is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Coumarin for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Coumarin could have any negative effects on these vulnerable groups. It should be safe to use Coumarin in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Coumarin for long period in food for newborns or pregnant.
Though Coumarin is not on FDA's GRAS exemption list, it's still widely accepted as safe food additive in many countries including USA with specific limit on dosage.
No breaking news or public health crises reported about Coumarin reported up to now.
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1. A TDDFT/EFP1 study on hydrogen bonding dynamics of coumarin 151 in water. [Spectrochim Acta A Mol Biomol Spectrosc. 2014 Aug 19]
Author: Ramegowda M.
2. Induction of Nur77-dependent apoptotic pathway by a coumarin derivative through activation of JNK and p38 MAPK. [Carcinogenesis. 2014 Sep 3]
Author: Zhou Y, Zhao W, Xie G, Huang M, Hu M, Jiang X, Zeng D, Liu J, Zhou H, Chen H, Wang GH, Zhang XK.
3. Antitumor effect of a copper (II) complex of a coumarin derivative and phenanthroline on lung adenocarcinoma cells and the mechanism of action. [Mol Med Rep. 2014 Aug 26]
Author: Zhu T, Chen R, Yu H, Feng Y, Chen J, Lu Q, Xie J, Ding W, Ma T.