Vitamin B12, CAS# 68-19-9, is a type of vitamin manufactured through chemical synthesis, available as Light red homogeneous powder. Vitamin B12 is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
Vitamin B12 might cause diarrhea, blood clots, itching, serious allergic reactions, and other side effects.
As Vitamin B12 is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Vitamin B12 for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
Vitamin B12 may have some affect on pregnant or breast-feeding women. We recommend consumers to consult professionals before using Vitamin B12 in food of pregnant or breast-feeding women.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Vitamin B12 is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Vitamin B12 reported up to now.
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1. The Effect of Vitamin B12 Infusion on Prevention of Nitrous Oxide-induced Homocysteine Increase: A Double-blind Randomized Controlled Trial. [Oman Med J. 2014 May]
Author: Kiasari AZ, Firouzian A, Baradari AG, Nia HS, Kiasari SH.
2. Vitamin B12 deficiency due to nitrous oxide use: unrecognized cause of combined spinal cord degeneration. [Rev Med Interne. 2014 May]
Author: Chaugny C, Simon J, Collin-Masson H, De Beauchêne M, Cabral D, Fagniez O, Veyssier-Belot C.
3. Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment. [Diabetes Obes Metab. 2013 Jul]
Author: Gatford KL, Houda CM, Lu ZX, Coat S, Baghurst PA, Owens JA, Sikaris K, Rowan JA, Hague WM.
4. Cognitive impairment and vitamin B12: a review. [Int Psychogeriatr. 2012 Apr]
Author: Moore E, Mander A, Ames D, Carne R, Sanders K, Watters D.
5. Oral vitamin B12 replacement: an effective treatment for vitamin B12 deficiency after total gastrectomy in gastric cancer patients. [Ann Surg Oncol. 2011 Dec]
Author: Kim HI, Hyung WJ, Song KJ, Choi SH, Kim CB, Noh SH.