Vitamin D3, CAS# 67-97-0, is a type of vitamin manufactured through chemical synthesis, available as YELLOW OR YELLOW BROWN,LIQUIDITY PARTICLES. Vitamin D3 is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As Vitamin D3 is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Vitamin D3 for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Vitamin D3 could have any negative effects on these vulnerable groups. It should be safe to use Vitamin D3 in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Vitamin D3 for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Vitamin D3 is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Vitamin D3 reported up to now.
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1. High-Dose Vitamin D3 Supplementation in Children and Young Adults with HIV: A Randomized, Placebo-Controlled Trial. [Pediatr Infect Dis J. 2014 Jul 1]
Author: Stallings VA, Schall JI, Hediger ML, Zemel BS, Tuluc F, Dougherty KA, Samuel JL, Rutstein RM.
2. Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study. [Ann Allergy Asthma Immunol. 2014 Apr]
Author: Rorie A, Goldner WS, Lyden E, Poole JA.
3. A Double-Blind, Placebo Controlled, Randomized Trial to Assess the Impact of a Monthly Administration of 50,000 IU of Vitamin D3 for 6 Months on Serum Levels of 25-Hydroxyvitamin D in Healthy Young Adults. [Int J Endocrinol. 2013]
Author: Brunel E, Schnitzler M, Foidart-Dessalle M, Souberbielle JC, Cavalier E.
4. Vitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and -9 in human uterine fibroid cells. [Hum Reprod. 2013 Sep]
Author: Halder SK, Osteen KG, Al-Hendy A.
5. A Randomised, Double-Blinded, Placebo-Controlled, Parallel Study of Vitamin D3 Supplementation with Different Schemes Based on Multiples of 25,000 IU Doses. [Int J Endocrinol. 2013]
Author: Cavalier E, Faché W, Souberbielle JC.