Cynarin, CAS# 30964-13-7, is a Plant extracts manufactured through plant extraction, available as Brown fine powder. Cynarin is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As Cynarin Side Effects is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Cynarin Side Effects for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Cynarin Side Effects could have any negative effects on these vulnerable groups. It should be safe to use Cynarin Side Effects in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Cynarin Side Effects for long period in food for newborns or pregnant.
Though Cynarin Side Effects is not on FDA's GRAS exemption list, it's still widely accepted as safe food additive in many countries including USA with specific limit on dosage.
No health issues about Cynarin Side Effects reported up to now.
1. Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.). [J Enzyme Inhib Med Chem. 2015 Mar 20]
Author: Topal M, Gocer H, Topal F, Kalin P, Köse LP, Gülçin İ, Çakmak KC, Küçük M, Durmaz L, Gören AC, Alwasel SH.
2. Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells. [Molecules. 2014 Mar 24]
Author: Xia N, Pautz A, Wollscheid U, Reifenberg G, Förstermann U, Li H.
3. [Development and validation of method for the determination of cynarin, luteolin in plasma]. [Przegl Lek. 2012]
Author: Kulza M, Malinowska K, Woźniak A, Seńczuk-Przybyłowska M, Nowak G, Florek E.
4. Inhibition of P-glycoprotein-mediated transport by S-adenosylmethionine and cynarin in multidrug-resistant human uterine sarcoma MES-SA/Dx5 cells. [J Biol Regul Homeost Agents. 2012 Jul-Sep]
Author: Angelini A, Di Pietro R, Centurione L, Castellani ML, Conti P, Porreca E, Cuccurullo F.