Proanthocyanidins, CAS# 18206-61-6, is a Plant extracts manufactured through plant extraction, available as Powder. Proanthocyanidins is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As Proanthocyanidins Side Effects is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Proanthocyanidins Side Effects for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Proanthocyanidins Side Effects could have any negative effects on these vulnerable groups. It should be safe to use Proanthocyanidins Side Effects in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Proanthocyanidins Side Effects for long period in food for newborns or pregnant.
Though Proanthocyanidins Side Effects is not on FDA's GRAS exemption list, it's still widely accepted as safe food additive in many countries including USA with specific limit on dosage.
No health issues about Proanthocyanidins Side Effects reported up to now.
1. Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1. [Int J Mol Med. 2012 Dec]
Author: Huang S, Yang N, Liu Y, Gao J, Huang T, Hu L, Zhao J, Li Y, Li C, Zhang X.
2. Grape seed proanthocyanidins inhibit angiogenesis via the downregulation of both vascular endothelial growth factor and angiopoietin signaling. [Nutr Res. 2012 Jul]
Author: Huang S, Yang N, Liu Y, Hu L, Zhao J, Gao J, Li Y, Li C, Zhang X, Huang T.
3. An overview of cancer chemopreventive potential and safety of proanthocyanidins. [Nutr Cancer. 2011 Nov]
Author: Ouédraogo M, Charles C, Ouédraogo M, Guissou IP, Stévigny C, Duez P.
4. Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation, and angiogenic factors. [Clin Cancer Res. 2009 Feb 1]
Author: Akhtar S, Meeran SM, Katiyar N, Katiyar SK.