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 Melatonin Side Effects

    Melatonin Side Effects

    by Shawn 2014-09-21

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    General Side Effects

    No significant side effects reported.


    * Report new side effects to us by sending email to foodchemmis08@foodchem.cn. Our expert will review it and respond soon.

    Suggested Dosage

    As Melatonin is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Melatonin for long period.


    * ADI: Acceptable Daily Intake
    * MTDI: maximum tolerable daily intake
    * Data source: JECFA Database of WHO

    Special Groups Precaution

    Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
    There is no evidence that Melatonin could have any negative effects on these vulnerable groups. It should be safe to use Melatonin in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Melatonin for long period in food for newborns or pregnant.

    GRAS Affirmation: Yes

    Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Melatonin is considered safe by FDA according to existing data and granted GRAS status.

    in News

    No breaking news or public health crises reported about Melatonin reported up to now.
    * Want to report news about this ingredient, please send email to foodchemmis08@foodchem.cn. Your knowledge can help us to uncover more truthes about food ingredients to customers.

    Related Research

    1. Melatonin is formed during winemaking at safe levels of biogenic amines. [Food Chem Toxicol. 2013 Jul]
    Author: Rodriguez-Naranjo MI, Ordóñez JL, Callejón RM, Cantos-Villar E, Garcia-Parrilla MC.

    2. The use of high-dose melatonin in liver resection is safe: first clinical experience. [J Pineal Res. 2011 May]
    Author: Nickkholgh A, Schneider H, Sobirey M, Venetz WP, Hinz U, Pelzl le H, Gotthardt DN, Cekauskas A, Manikas M, Mikalauskas S, Mikalauskene L, Bruns H, Zorn M, Weigand MA, Büchler MW, Schemmer P.

    3. Melatonin is a safe and effective treatment for chronic pulmonary and extrapulmonary sarcoidosis. [J Pineal Res. 2006 Sep]
    Author: Pignone AM, Rosso AD, Fiori G, Matucci-Cerinic M, Becucci A, Tempestini A, Livi R, Generini S, Gramigna L, Benvenuti C, Carossino AM, Conforti ML, Perfetto F.

    4. Urgent search for safe and effective treatments of severe acute respiratory syndrome: is melatonin a promising candidate drug? [J Pineal Res. 2003 Aug]
    Author: Shiu SY, Reiter RJ, Tan DX, Pang SF.



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