Chondroitin Sulfate, CAS# 9088-44-2, is a organic compound manufactured through chemical synthesis, available as White to off-white Powder. Chondroitin Sulfate is widely used as nutritional supplements. It is widely accepted as safe food additive in many countries.
It can cause some mild stomach pain and nausea. Other side effects that have been reported are diarrhea, constipation, swollen eyelids, leg swelling, hair loss, and irregular heartbeat.
As Chondroitin Sulfate is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Chondroitin Sulfate for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
Chondroitin Sulfate may have some affect on pregnant or breast-feeding women. We recommend consumers to consult professionals before using Chondroitin Sulfate in food of pregnant or breast-feeding women.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Chondroitin Sulfate is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Chondroitin Sulfate reported up to now.
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1. Ternary complex of plasmid DNA electrostatically assembled with polyamidoamine dendrimer and chondroitin sulfate for effective and secure gene delivery. [Biol Pharm Bull. 2014]
Author: Imamura M, Kodama Y, Higuchi N, Kanda K, Nakagawa H, Muro T, Nakamura T, Kitahara T, Sasaki H.
2. Combined intravesical sodium hyaluronate/chondroitin sulfate therapy for interstitial cystitis/bladder pain syndrome: a prospective study. [Ther Adv Urol. 2013 Aug]
Author: Giberti C, Gallo F, Cortese P, Schenone M.
3. Symptom and structure modification in osteoarthritis with pharmaceutical-grade chondroitin sulfate: what's the evidence? [Curr Med Res Opin. 2013 Mar]
Author: Hochberg M, Chevalier X, Henrotin Y, Hunter DJ, Uebelhart D.
4. Combination of chondroitin sulfate and polyplex micelles from Poly(ethylene glycol)-poly{N'-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity. [J Control Release. 2011 Oct 30]
Author: Uchida S, Itaka K, Chen Q, Osada K, Miyata K, Ishii T, Harada-Shiba M, Kataoka K.
5. Chondroitin sulfate capsule system for efficient and secure gene delivery. [J Pharm Pharm Sci. 2010]
Author: Kurosaki T, Kitahara T, Fumoto S, Nishida K, Yamamoto K, Nakagawa H, Kodama Y, Higuchi N, Nakamura T, Sasaki H.