No significant side effects reported. D-Ribose can cause diarrhea, stomach discomfort, nausea, headache, and low blood sugar in specific groups of individuals.
As D-Ribose is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of D-Ribose for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that D-Ribose could have any negative effects on these vulnerable groups. It should be safe to use D-Ribose in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of D-Ribose for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. D-Ribose is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about D-Ribose reported up to now.
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1. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. [J Clin Pharmacol. 2013 Nov 23]
Author: Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R.
2. Evaluation of α-D-ribofuranose (D-ribose) toxicity after intravenous administration to rabbits. [Hum Exp Toxicol. 2012 Aug]
Author: Ismail ZB, Abu-Baker N, Alzoubi K, Al-Zhgoul M, Al-Essa MK, Khlouf S, Al-Saleh A, Al-Omari B, Abu-Tayeh R, Shomaf M, Battah A, Al-Hadidi K.
