L-Alanine, CAS# 56-41-7, is a amino acid manufactured through fermentation, available as white crystal powder. L-Alanine is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported. L-alpha-alanine can increase blood sugar levels in people with diabetes.
As L-Alanine is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of L-Alanine for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that L-Alanine could have any negative effects on these vulnerable groups. It should be safe to use L-Alanine in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of L-Alanine for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Alanine is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about L-Alanine reported up to now.
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1. Characterization of a meso-chiral isomer of a hexanuclear Cu(ii) cage from racemization of the l-alanine Schiff base. [Dalton Trans. 2014 Jul 15]
Author: Rajesh CM, Ray M.
2. Structural Analysis and Mutant Growth Properties Reveal Distinctive Enzymatic and Cellular Roles for the Three Major L-Alanine Transaminases of Escherichia coli. [PLoS One. 2014 Jul 11]
Author: Peña-Soler E, Fernandez FJ, López-Estepa M, Garces F, Richardson AJ, Quintana JF, Rudd KE, Coll M, Vega MC.
3. Prolonged continuous intravenous infusion of the dipeptide L-alanine- L-glutamine significantly increases plasma glutamine and alanine without elevating brain glutamate in patients with severe traumatic brain injury. [Crit Care. 2014 Jul 2]
Author: Nägeli M, Fasshauer M, Sommerfeld J, Fendel A, Brandi G, Stover JF.
4. Thiophenyl-substituted triazolyl-thione L-alanine: asymmetric synthesis, aggregation and biological properties. [Amino Acids. 2014 Jun 22]
Author: Saghyan AS, Simonyan HM, Petrosyan SG, Geolchanyan AV, Roviello GN, Musumeci D, Roviello V.
5. Cycling Time Trial Performance May Be Impaired by Whey Protein and L-Alanine Intake During Prolonged Exercise. [Int J Sport Nutr Exerc Metab. 2014 Jun 17]
Author: Schroer AB, Saunders MJ, Baur DA, Womack CJ, Luden ND.