Neohesperidin, CAS# 13241-33-3, is a Plant extracts manufactured through plant extraction, available as white yellow powder. Neohesperidin is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
No significant side effects reported.
As Neohesperidin is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Neohesperidin for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Neohesperidin could have any negative effects on these vulnerable groups. It should be safe to use Neohesperidin in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Neohesperidin for long period in food for newborns or pregnant.
Though Neohesperidin is not on FDA's GRAS exemption list, it's still widely accepted as safe food additive in many countries including USA with specific limit on dosage.
No health issues about Neohesperidin reported up to now.
1. Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-Ay mice. [Food Funct. 2015 Jan 26]
Author: Jia S, Hu Y, Zhang W, Zhao X, Chen Y, Sun C, Li X, Chen K.
2. Development of new reference material neohesperidin for quality control of dietary supplements. [J Sci Food Agric. 2014 Aug 29]
Author: Gong N, Zhang B, Yang D, Gao Z, Du G, Lu Y.
3. Effect of hesperidin and neohesperidin from bittersweet orange (Citrus aurantium var. bigaradia) peel on indomethacin-induced peptic ulcers in rats. [Environ Toxicol Pharmacol. 2014 May]
Author: Hamdan DI, Mahmoud MF, Wink M, El-Shazly AM.
4. Neohesperidin attenuates cerebral ischemia-reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway. [J Asian Nat Prod Res. 2013 Sep]
Author: Wang JJ, Cui P.
5. Neohesperidin induces cellular apoptosis in human breast adenocarcinoma MDA-MB-231 cells via activating the Bcl-2/Bax-mediated signaling pathway. [Nat Prod Commun. 2012 Nov]
Author: Xu F, Zang J, Chen D, Zhang T, Zhan H, Lu M, Zhuge H.